Hot Flashes and Botox Study

      
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  HEALTH NEWS, WFAA-TV, Dallas, 10/2/08

Study aims to cool off hot flashes

09:04 AM CDT on Thursday, October 2, 2008

By JANET ST. JAMES / WFAA-TV

DALLAS - For women, the signs of a hot flash are unmistakable.

Hot flashes study
Oct. 2, 2008 View larger E-mail Clip More Video "You feel clammy, like right now," said Sara Lester, who has endured hot flashes for 15 years.

Sick of suffering, she slipped into a skin-tight, scuba-type suit for an unusual experiment at Presbyterian Hospital.

"We know with a hot flash the skin increases blood flow and it sweats, but we really don't know why that is and what's going on with the body," said Craig Crandall, UT a Southwestern researcher.

Lester's body is among the menopausal volunteers wired and monitored to find out specifically which nerves are triggered by hormones in a hot flash.

As a second part of the experiment, researchers are using Botox. Botulinum toxin is known to paralyze nerves responsible for wrinkles. It also blocks the sweating response.

So, scientists are working to see if Botox works for hot flashes.

"Botox prevents certain nerves from firing," Crandall said.

For this hot flash experiment, only browline nerves that are set off in a hot flash are being injected with Botox. Scientists want to see if the patient gets relief from heat and perspiration in the forehead area in the weeks following the Botox treatment.

"With that information, then perhaps we can find other agents that might be not like Botox but have similar effects without adverse affects, because clearly we're not going to give Botox throughout the body," Crandall said.

This trial is only in the beginning phases.

But, researchers are looking for more menopausal volunteers to give the experiment a try. The ultimate hope is to develop new drugs to stop symptoms of a hot flash. They believe if Botox works, it could be a win-win situation for women.

Those looking for information on the study can contact Jena Porterfield, RN at 214-345-4610.

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